Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations

نویسندگان

  • Derek J. Hausenloy
  • Hans Erik Botker
  • Thomas Engstrom
  • David Erlinge
  • Gerd Heusch
  • Borja Ibanez
  • Robert A. Kloner
  • Michel Ovize
  • Derek M. Yellon
  • David Garcia-Dorado
چکیده

Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore; The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK; National Institute of Health Research University College London Hospitals Biomedical Research Centre, London W1T 7DN, UK; Department of Cardiology, Aarhus University Hospital Skejby, DK-8200 Aarhus N, Denmark; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Cardiology, Lund University, Lund, Sweden; Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; IIS-Fundación Jiménez Dı́az Hospital, Madrid, Spain; Huntington Medical Research Institutes, Pasadena, CA, USA; Division of Cardiovascular Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Explorations Fonctionnelles Cardiovasculaires, Hôpital Louis Pradel, Lyon, France; UMR 1060 (CarMeN), Université Claude Bernard, Lyon, France; and Department of Cardiology, Vall d’Hebron University Hospital and Research Institute, Universitat Autònoma, Pg Vall d’Hebron 119-129, 08035 Barcelona, Spain

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Study of the Duration, Outcomes, and Related Factors of Reperfusion Therapy in Patients with ST-Segment Elevation Myocardial Infarction

Background and Objective: One of the most important advancements regarding the care of patients with acute myocardial infarction is the administration of anti-coagulation medicines (e.g., streptokinase). However, it must be noticed that this medicine requires rapid and timely administration. Moreover, Percutaneous Coronary Intervention (PCI) is increasingly used as a method of revascularization...

متن کامل

Pharmacological agents for reducing myocardial infarct size in ST-segment elevation myocardial infarction

Major progress has been made over the last two decades for the treatment of patients with ST-segment elevation myocardial infarction (STEMI). The major objective of this treatment is to reduce infarct size, which is the major prognostic factor in this population. Most of the efforts have been focused on improving reperfusion therapy in order to open as quickly as possible the culprit coronary a...

متن کامل

Prehospital and interhospital delay in the treatment of patients with acute myocardial infarction with ST segment elevation and strategies to improve it from the perspective of the process owners: The importance of time

Introduction: Fibrinolytic drugs are one of the important strategies for the treatment of patients with acute myocardial infarction with ST segment elevation, especially in small centers. This study was conducted with the aim of evaluating the distance with the global standard for fibrinolytic treatment and the viewpoints of experts in this regard. Materials and Methods: This cross-sectional st...

متن کامل

بررسی تغییرات قطعه‌ی ST در روش 15 اشتقاقی در بیماران مبتلا به سندروم کرونری حاد

Background & Objective: Patients with ischemic heart disease classified to two major groups: patients with stable angina and patients with Acute Coronary Syndrome (ACS). Previous studies showed that posterior segment of left ventricle is a silent segment on ECG, and routine 12 leads electrocardiogram (ECG) is not sensitive for evaluation of posterior infarction. This study designed for evaluati...

متن کامل

The effect of oxygen inhalation on cardiac biomarkers in patients presenting with acute ST-segment elevation myocardial infraction: A randomized clinical trial

Background: It is assumed giving oxygen to patients with acute myocardial infraction may increase the oxygenation of the ischemic tissue; however, the usefulness of oxygen in these patients has become a challenging topic. Thus, the present study aimed to determine the effect of oxygen inhalation on cardiac biomarkers in patients with acute myocardial infarction.    Methods: This randomized cli...

متن کامل

Electrocardiographic left ventricular hypertrophy is not associated with increased in-hospital adverse events in patients experiencing first non-ST segment elevation myocardial infarction: A single center study

Background: There is conflicting data about prognostic implication of electrocardiographic (ECG) left ventricular hypertrophy (LVH) in patients with first non- ST-segment elevation myocardial infarction (NSTEMI). We aimed to examine the association of left ventricular hypertrophy (LVH) on admission electrocardiogram with adverse outcomes in patients with NSTEMI. Methods: In the present study, ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 38  شماره 

صفحات  -

تاریخ انتشار 2017